I am trying to learn more about their place in the PK/PD space
Hello, I have 5 blood samples each from 6 patients treated with a drug: on day 1 (before treatment), 7, 14, 21 and 30. In these samples I have measurement of both the drug concentrations and...
06 March 2024 6,595 2 View
Hey Folks, I am trying to install PK solver ad-in on a Mac with MS Excel 365 (64bit Version) (https://www.sciencedirect.com/science/article/abs/pii/S0169260710000209?via%3Dihub). However, I...
18 July 2023 6,743 4 View
Is it possible for a drug that it's duration of action time be bigger than it's clearance time?
17 January 2023 677 4 View
I am working on a development project for ELISA using human sample pools and a newly developed antibody drug. In this assay we use one set of QCs containing ULOQ,HQC, MQC, LQC, LLOQ. And a sets of...
24 January 2022 4,780 2 View
Trying to understand the relationship between t1/2 and dosing regimen (qd, bid, tid, ...). Are dosing frequencies for a drug approved based on t1/2 or other factor like AUC..etc? where can such...
13 December 2020 5,780 5 View
The drugs in question are mostly chronic maintenance drugs with PO, topical, ophthalmic and tube feeding route. What parameters determine dose intervals?
16 November 2020 10,172 3 View
I can fathom the idea of PK being different b/w dogs and rodents, but why would I be seeing a significantly different PK profile for the same drug tested on rats and mice?
10 September 2020 8,966 5 View
I have two types of data, one is 200 drugs' plasma concentrations, another is the binding affinity(Ki, Kd or IC50) between drug and its targets downloaded in Chembl database. Now I want...
10 March 2020 2,251 3 View
An anesthesiologist using a TCI system to administer an IV agent is able to set and change a target concentration, basing the choice of target concentration on observation of clinical effect....
21 April 2019 3,514 2 View
Can any one provide me a standard PK/PD protocol . for small molecule/ peptide?
31 December 2018 5,876 5 View
