Why are some drugs with very long half-life dosed multiple times a day ( e.g. Dexamethasone Q6H)?

Trying to understand the relationship between t1/2 and dosing regimen (qd, bid, tid, ...). Are dosing frequencies for a drug approved based on t1/2 or other factor like AUC..etc? where can such...

13 December 2020 5,532 5 View

What is the difference between BID (twice a day) and Q12H drug dosing? Can drugs with BID dose regimen be switched to every 12 hours?

The drugs in question are mostly chronic maintenance drugs with PO, topical, ophthalmic and tube feeding route. What parameters determine dose intervals?

16 November 2020 9,895 3 View

What factors may contribute to the PK differences in rats and mice?

I can fathom the idea of PK being different b/w dogs and rodents, but why would I be seeing a significantly different PK profile for the same drug tested on rats and mice?

10 September 2020 8,697 5 View

How to compare drug plasma concentration with drug-target binding affinity?

I have two types of data, one is 200 drugs' plasma concentrations, another is the binding affinity(Ki, Kd or IC50) between drug and its targets downloaded in Chembl database. Now I want...

10 March 2020 2,174 3 View

Does anyone has a standard PK/PD protocol?

Can any one provide me a standard PK/PD protocol . for small molecule/ peptide?

31 December 2018 5,739 5 View

Working on PK/PD of Phyto-constituent, oral acute toxicity have LD of 5000mg/Kg on Mice. What should be dose for Rat in IV & Oral for performing PK?

I am working on PK/PD of Phyto-constituent, I have a data on oral acute toxicity have LD of 5000mg/Kg on Mice. What should be dose for Rat in IV & Oral for performing PK? How to perform the...

31 December 2018 516 2 View

Please anyone can send below full text pdf article to me?

11 December 2018 1,303 0 View

Can I reduce a nitro group to an amine with Pd/C, if there is an HCl salt of an amine in the molecule?

My molecule that I am trying to reduce has an aryl nitro group and a tertiary amine on it. I am looking to make the HCl salt of the amine to additionally purify the molecule. My next step in my...

13 November 2018 9,162 3 View

Would you normalise data in a bio-availability study, how would you do it and why?

It's a comparison of liposomal vitamin C to non-liposomal vitamin C. There were 21 geometric mean data points taken from each test group. I have the SD for each data point, there is some...

10 November 2018 8,448 4 View

Can I reduce a nitro group to an amine with Pd/C, if there is an HCl salt of an amine in the molecule?

My molecule that I am trying to reduce has an aryl nitro group and a tertiary amine on it. I am looking to make the HCl salt of the amine to additionally purify the molecule. My next step in my...

10 November 2018 4,985 4 View