I am interested in researching intermittent fasting (IF) and caloric restriction (CR) in relation to hypothesized positive effects on oxidative stress in the nervous system, specifically in the aging, possibly pre-AD brain. I will be using a zebrafish model to study the topic. I am currently in the process of doing a general lit review on the topic, but will be thankful for any insight/difficulties with collecting similar research in the species. It'd be great to have a light shone on any articles I might miss (any species). Thank you for taking the time to read and answer!
Since oxidative stress and inflammation have a mutual relationship, dietary or caloric restriction has been proposed recently to ameliorate neuroinflammatory diseases and decrease aging process. However, SIRT 1 pathway has been found to be involved in regulating the cellular redox and inflammation response.
Article Caloric restriction: Beneficial effects on brain aging and A...
Following is a review regarding the topic.
Hope it can help you
Article Practicality of Intermittent Fasting in Humans and its Effec...
Hi there
It's an awesome project, but I don't know the purpose to choosing zebrafish as a model, I also recommend the following review article (link) for you.
Best
https://www.ncbi.nlm.nih.gov/m/pubmed/15741046/
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