Dear Marek.

Your doubts can dispel the clinical practice of amantadine (Symmetrel) in Japan:

http://dictionary.goo.ne.jp/leaf/kusuri/3446/m0u/

https://www.data-index.co.jp/knowledge/detail4-3.html

http://database.japic.or.jp/pdf/newPINS/00062455.pdf

http://kusuri-jouhou.com/medi/parkinson/amantadine.html

There are many other sources, confirming the effectiveness of amantadine in rehabilitation therapy after traumatic brain injury:

http://www.medscape.com/viewarticle/759591

http://www.nejm.org/doi/full/10.1056/NEJMoa1102609#t=article

https://www.ncbi.nlm.nih.gov/pubmed/7849690

http://www.mdedge.com/neurologyreviews/article/73352/traumatic-brain-injury/amantadine-may-hasten-functional-recovery

Evidence of effectiveness in clinical practice collected a lot. No detailed description of the mechanism of action at the cellular level. But the basic (primary) operating principles amantadine described in many studies.

(http://www.genome.jp/dbget-bin/www_bget?dr_ja:D00777)

Regards

Dear marek.

In my project about traumatic brain injury amantadine also used for the positive control group..

No.