One would expect that due to the protein nature of enzymes, sooner or later the mTOR signaling system would eventually develop an immune dysregulation. This opens the door to hardcore evidence to "The Immunological Theory of Aging" given the close links of mTOR and the aging process. It wouldn't be strange to find high levels of IgM or IgG in patients with progeria. The close relationship between free radicals and aging (Harman, The free radical theory of aging) and mTOR would constitute the thesis, antithesis and synthesis of the molecular biology of aging.
The following reference might help you.
Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options
G Pignataro, D Capone, G Polichetti - 2011 - Elsevier
mTOR inhibitors: current and emerging therapeutic options. ... Classification of mTOR inhibitors.
The mTOR pathway is not related to mechanism of natural aging, therefore it unable to be the basis for elaboration of radical remedy for senescence (see: Trubitsyn A.G. “The Lag of the Proliferative Aging Clock Underlies the Lifespan-Extending Effect of Calorie Restriction” Current Aging Science, 2015, 8, 220-226.) ;� };��Q*G��ȵK�9
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology