Dear Hitoshi,

Yes, we use additive solutions both for pool (buffy-coat derived) platelet concentrates (PC) and apheresis PC. Both in 100%; for buffy-coat derived PC: T-Sol by Fenwal or SSP by Macopharma; no additive solution-associated problems.

Best,

Markus

Hi Hitoshi,

In our Hospital we transfuse platelet concentrates in SPP, prepared in Reveos machines (Terumo BCT). No problems.

Best,

Miguel

Hi,

Yes, we have used platelet additive solutions in 99% of our production (both buffy-coat and apheresis platelets) for more than 6 years. We use mainly SSP but occasionally also T-sol. There are only advantages and no problems.

Dear Hitoshi

So far, these solutions are not licensed in Brazil. Regards

Dear Hitoshi,

Yes we are using platelet additive solutions both trombosol (PAS2) as well as intersol (PAS3). I think about 1/3 of our platelet concentrates are in additive solution. As far as I know we see no problems.

Dear Hitoshi,

Yes, we use the T-SOL additive solution from Fenwal. We use it in 100% of our Pooled Platelet production and we have had no reported additive solution-associated problems. Our annual production is approximately 32 500 units.

Regards

Robyn

Dear Hitoshi,

1. Yes we use PAS for all platelet concentrates (both apheresis and buffy-caot derived). We use Intersol in a ratio of 39% plasma / 61% Intersol. This ratio comes from the Intercept PI technique specification (32-47% plasma; whereas 100% plasma is feasible, it poses other operational constraints - longer procedure basically).

2. 100% of platelet components. For apheresis we use 500 mL Intersol bags with automatic addition of Intersol on Trimas. For Buffy coat platelets, we use 280 mL Intersol bags, automatically added on the Orbisac machine during pooling of BC.

3. The transition from 100% plasma to 39% plasma /61% Intersol for paltelet storage has been associated in Switzerland with a significant decrease of transfusion reactions:

https://www.swissmedic.ch/marktueberwachung/00138/00188/index.html?lang=de&download=NHzLpZeg7t,lnp6I0NTU042l2Z6ln1acy4Zn4Z2qZpnO2Yuq2Z6gpJCDdn18fWym162epYbg2c_JjKbNoKSn6A--

Whereas the document compares pre- and post Intercept (pathogen inactivation technique) introduction, the main difference for non-infectious transfusion reactions comes from the use of additive solution instead of 100% plasma.

Regards

Niels