As a toxicologist, I am very interested in the presence of various OATPs (membrane trasporters) in cell lines that are very often used in various toxicological and pharmaceutical studies. The information about OATPs in cell lines are very limited.
Do you know some review or source of information, where can I find what OATPs are present in the cell lines (e.g. HEK293, Hela or HekG2)?
Thank you in advance.
the Proteinatlas can be a great resource for this:
http://www.proteinatlas.org/cell
Yes, this link would answer at least some of my questions.
Thank you for fast a relevant response!
The OATP expression is generally low in HEK293 cells unless you transfect them with the transporter of interest. In the link below, you find a study of transporter expression in HEK293 and HeLa cells).
http://www.ncbi.nlm.nih.gov/pubmed/19741037
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