As part of an effort to explore the epigenetics of ageing, we have collected matched saliva and peripheral blood via fingerprick. Understanding patterns across different tissues may be similar, the literature on the equivalence of DNA from saliva and DBS is sparse, and would appreciate any unpublished/published data/results.
Hi Paul, I don't know if this will help you, but my company was looking at using saliva to measure diabetic markers found in plasma.
There is diffusion of proteins from plasma to saliva.
Anyway, we found that most saliva samples are contaminated by bacterial proteins and bacterial DNA.
The short answer is no. Saliva is contaminated in ways the peripheral blood is not. There appear to be differences between labs as well. But it should be fine if you are running a clinical trial. You just need to be careful about power because the variance will be larger in saliva than blood.
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