The non-uniformity and heterogeneity of the geological, geographical, and therefore hydrogeological settings account for the large diversity of karst types identified over the world. As we know, the rocks have different hydrogeological behaviors as a result of factors that controlling karstification in the extending area such as lithostratigraphy, energy gradient, tectonic activity, erosion base, and climate change, followed by a number of other factors. The tectonic activity is the one of the major factor in karstification. As you know, the primary porosity is very low in carbonate rocks. The discontinuities (fault plane, fracture system, etc.) comprise secondary porosity in these rocks. Thus, secondary porosity host presences of water and create suitable pathway for water circulation in carbonate rocks. I think that it is important to initiation of karstification. You should keep in mind other factors in evaluation of karst.
It depends on what you mean by important.... As limestone is an impervious rock the possibility for water to circulate in a block depends on the presence of open cracks and joints. Meanwhile their orientation is not the main factor for karst developpment. For epigenic caves, the most important is the hydraulic gradient. (It is like electricity that uses the less resistive way). The water runs from a feeding part (unique or diffuse) to an outlet (spring) whose position is determined by the respective geometry of base level (river, lake, sea), limestone block and impervoius series. Fractures are just a possible way to reach the outlet. Water will preferentially use the fractures that are open and whose orientation is close to the flow direction. If a main fracture is perpendicular to the circulation it will be poorly enlarged.
As most systems are polyphase karst, the variations of base level position and tectonics strengths may change the water circulation.
See the numerous publication by Paul L. Broughton on the subject of underlying salt dissolution tectonics controlling the collapse of hypogene karst in western Canada
Yea, its correct. Fracture systems are very important in karstification but fractures must connected with together. fractures that are not connected to each other do not have great importance in karstification.