sorry

Dear Jaebeom,,

I don't have access to PubMed right at the moment, but if memory serves, Peter Bryant's lab at the University of California, Irvine, published something on this.

Cheers!

Jill

A great deal of progress has been made in understanding the cellular and molecular mechanisms that underlie proliferation and cell-fate decision in the Drosophila brain neuroblast model. A surprising aspect of this progress is the recent demonstration that key molecular control elements involved in asymmetric cell-fate determination in normal neuroblast lineages are also central elements in neuroblast-derived brain tumor formation. Further research in Drosophila and in other model systems is required to determine how the process of self-renewal and differentiation operates in normal neural stem cells and neural stem cell-derived cancer. Fortunately, the remarkable conservation of major transcriptional control and signaling pathways between flies and humans makes these studies of neural stem cells in Drosophila highly valuable for human stem cell biology. Thus, investigations in mammalian systems focused on the roles of those key factors for neural stem cell proliferation that have been identified in Drosophila are likely to be a gateway for a better understanding of many human cancers and further for developing therapeutic designs. Moreover, a sound understanding of the mechanisms underlying tumorigenic perturbations of neural stem cells is clearly a prerequisite for any potential development of neural stem cell-based therapy in humans.