Need your suggestions regarding computational tools.
Do you mean a drug interaction checker?
https://www.webmd.com/interaction-checker/default.htm
https://reference.medscape.com/drug-interactionchecker
https://www.rxlist.com/drug-interaction-checker.htm
@Karunrat Tewthanom
Yes exactly but I also want to know how we computationally identify drug interaction with other diseases for drug repositioning. Suppose a drug is particularly used for viral disease but I want to identify the interaction with other disorders. How much this drug is effective against other diseases as like viral disease.
Check out this paper, it would help regarding drug-drug interaction if that was your question:
https://link.springer.com/article/10.1007%2Fs00228-014-1786-7
My recommendation is Lexi-interact and Micromedex-interact
Regarding your second question:
you need to know about the pharmacology (receptor and binding) also the medicinal chemistry aspect of the drug (docking).
There are free and paid software for DDI checkers. To name a few Medscape, Drug.com, Epocrete are freely available and Other paid software are Micromedic, Lexicom and Up-to-date.
There have been several deep learning frameworks in recent years for DDI and DTI, and most of them provide their dataset and code, I can link some for you, however, you will need some understanding of python and the Keras library to reproduce their results and use it for you own datasets.
https://github.com/nrohani/NDD
https://github.com/suyumei/DrugDrugIntact
University of Liverpool, it depends on the pathology:
https://www.covid19-druginteractions.org/
https://www.hiv-druginteractions.org/
https://www.hep-druginteractions.org/
We use Clinical Pharmacology. I converted my colleagues to it which was not difficult - it's by far the best. Interactions are ranked Level 1 (do not combine ever) to Level 4 (minor interaction with few/no effects typically seen). ClinPharm will often find different and much more factual interaction data when compared to Unix-based 'First Data Bank' which unfortunately is the default checker used by many health information systems. See: clinicalkey(dot)com/pharmacology
Most commonly used DDI Checkers:
Micromedex®, Portable Electronic Physician Information Database©, UpToDate®, Medscape.com drug interaction checker, Drugs.com drug interaction checker
If you are a student i would highly recommend to visit Drugs.com and check for interactions.
First create an account for free and then you are good to go
if you want more details you can also switch to advanced mode
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