I just came across an Open Source application called KNIME which has some serious potential for data mining and analysis, model generation, and possibly design of experiment applications. You can find it here:

http://tech.knime.org/home

It has some integration with R that I have not yet explored, and I have encountered a reference from someone integrating Eureqa (one of my favorite programs for curve fitting) into the project.

KNIME has a very intuitive GUI and good documentation- five minutes to install and run the first example program. One thing it provides that helps me with one of my personal great failings is that it provides a record of the path from data to results- all too often, by the time I get the results I am after, I have forgotten the details of the path I took! Looks like a very powerful tool.

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