The Galvani's experiment on electrical stimulation the leg of a frog as well as the Hodgkin–Huxley mathematical model, or electrical conductance-based model, that describes how action potentials of neurons are generated and propagated are considered as fundamental basics of neurophysiology. However, electrophysiology as the major subject of neurology has reached to the dead end not only in the brain activity (or heart) comprehension, but also to an underestimation of the neurons functioning.

The corpus callosum is the largest white matter structure in the human brain, consisting of 200–300 million axonal projections. If the brain would be functioning based on electrical pulses of neurons, the corpus callosum (as well as other neuronal tractus) could not be able to translate unique information to the specific nuclei or brain cortex location in the presence of dissipation and interferences of neuronal pulses electrical fields.

As an alternative information transmission channel between neurons and nerve centers, optical communication between cells can be much more efficient, faster, and even less power-consuming. And what is much more important is being addressing and interference-resistance.

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