Could dantrolene enhance exon skipping and increase revertant fibers in severe dystrophinopathy with quite a few spontaneous revertant fibers already?

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Vikki Stefans

This is an unusual point deletion in exon 31 with part of intron 30 missing too. We do suspect there is some alternative splicing going on.

Corrado Angelini

In a previous study (Fanin et al. Muscle &Nerve.1995) in 135 DMD cases the number of revertant fibers increased witha age , we suggested that reversion might happen in satellite cells ,may be dantrolene can affect fusion of satellite cells and musle fibers.