a) Yes, it's obvious. They show better magnetic properties.
b) Yes, but they are far from clinical applications.
c) Perhaps, but I'm not sure. More experiments are needed.
d) No, as they may be more toxic.
e) Not at all. Isotropic ones are the best.
What do you think? Feel free to write your comments and interesting references on this topic, please.
Anisotropic SPIONs can be useful but it depends on their alignment.
Regarding toxicity, many studies on functionalized SPIONs ranging from simple PEGylation to more complex coatings..
And recent research in functionalization of SPIONs has graduated from the basic functionality of biocompatibilzation to more complex hormone, drug releasing agents etc.. Visit Warren group@Duke university
http://www.chem.duke.edu/~wwarren/spion.php
What I have seen is that it is possible to increase the sharpness of the image, reducing the size of the nanoparticle. A shape anisotropy may increase the magnetic moment, but it can also block access to certain regions.
Thank you for your kindly answers, V.M. Lenart and Sridhar Vahanambi.
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