If the answer is positive, what are the geometric criteria and what docking programs could handle this?
Tarak Karamakar
The definition of H-bond donor and acceptor got changed from the classical perspective to a more generalised cocept. These alkyl Hydrogens can also act as very very weak hydrogen bond donor, and thus shows weak H-bonding with polar ( H-acceptor) sites. As suggested earlier, it is very hard to asses this phenomenon by means of classical simulations or docking studies. More accurate quantum ( ab initio) calculations or for large system, QM/MM, are required in this context.
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Saleem Naser
i think smal instantaneous charge formed in aliphatic compound if mixed with cation (wander wal force ) there is no hydrogen bonding interaction can formed.
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