lack of a technology for keeping huge amount of data generated here and there
High-cost of agricultural raw material for bioprocessing
Low-cost raw materials, such as cellulose, can not be easily used for microbial process
High-cost of downstream processing of biomolecules etc....
Hello
1.Petroleum does not rise in price too much after 2008 financial crisis, other alternative energy sources, especially shale gas, natural gas hydrate (or gas hydrate) and sand oil, have been discovered in large amount and their exploitations are increasingly moving toward a very competitive price;
2.The exhaustion of petroleum seems to be a remote reality
3.Agriculture raw materials for bioprocessing are becoming increasingly costly
4.Low cost raw material cellulose can not be easily used for microbial processes at least for the next 5–10 years
5.Bioprocessing is still not as effective as chemical processing, resulting in high cost of bio-products
6.Bioprocessing that requires large amount of fresh water has had increasing concerns in many water shortage areas
7.The chemical industry is also evolving competitive in various ways including environmentally friendliness, the use of renewable resources (biomass) for making chemicals that are normally derived from petro-chemicals
8.The rapid development of C1 chemical engineering products
9.Large amount of funding is not more directed to industrial biotechnology.
see full text in this link : https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-11-111
Good Luck
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