The principles of Green Chemistry offer a paradigm shift in nuclear waste management by transforming problematic materials like depleted uranium (DU) and fission products into valuable resources for energy and industrial applications while minimizing environmental impact. This approach aligns with circular economy objectives by viewing nuclear byproducts as potential feedstocks rather than waste requiring disposal. Depleted uranium's unique properties including its exceptional density and radiation shielding capacity make it suitable for innovative applications such as counterweights in renewable energy systems like wind turbines, where it can improve stability and efficiency, or as a safer alternative to lead in radiation shielding for medical and industrial uses. Certain fission products like cesium-137 and strontium-90 can be repurposed as long-lasting power sources in radioisotope thermoelectric generators for space exploration and remote monitoring stations, providing clean energy where conventional power is impractical. The recovery of valuable metals from nuclear waste streams, including platinum group metals and rare earth elements, can be achieved through environmentally benign processes like bioleaching or electrochemical separation, significantly reducing the need for traditional mining and its associated ecological damage. Green Chemistry further contributes by developing non-toxic methods to convert tributyl phosphate (TBP) into useful agricultural phosphates and by creating radiation-resistant materials that incorporate nuclear waste into durable products like specialized ceramics. Advanced separation techniques using ionic liquids or supercritical fluids enable more efficient and less hazardous processing compared to conventional methods, while biomining approaches leverage natural biological processes to extract valuable components without generating secondary pollution. The integration of real-time monitoring systems ensures safe handling throughout these valorization processes, and life-cycle assessments validate the environmental benefits of these approaches. By applying Green Chemistry principles from waste prevention and atom economy to safer solvent use and catalytic processes the nuclear industry can transition toward a more sustainable model where waste streams become sources of materials for clean energy technologies, industrial applications, and advanced materials, ultimately reducing both environmental impact and reliance on virgin resources. This transformation requires continued research into scalable green processing methods, along with policy frameworks that incentivize the development of nuclear waste valorization technologies, creating a pathway for nuclear energy to contribute more fully to a circular, sustainable economy.