Hi,
Has anyone seen/studied an article about the MD simulation of car t cell therapy? Whats your opinion about this project?
Molecular dynamics (MD) simulation can be applied to any molecular model.
If you are interested in (inter/intra)-(bio)-(macro)-molecular interaction(s) and if you ask questions relevant to Chimeric Antigen Receptor (CAR) T-cell therapy that can be answered by MD simulations (e.g., about the nature and strength of interaction between a CAR on the T-cell and an antigen on the cancer cell), or if MD simulation will give you ideas for additional experiments relevant to CAR T-cell therapy, then, yes, MD simulations are useful in such a project.
Basically, in T cell therapy signalling proteins play a central role. Estimation of protein-protein interaction can be done by MD simulation. For example, impact of mutation to the protein-protein interaction or blockage of protein-protein interaction by means of specifically designed peptides and etc.
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