Dear researchers, I'm trying to prepare a molecular imprited polyer(MIP), my template contains a long alkane group, I tried to synthesize a molecularly imprinted polymer layer on my support material using methacrylamide as the functional monomer and ethanol as the solvent by precipitation, but failed.I encountered the following problems during the experiment:
1、NIP is easy to synthesize and the polymerization is too fast within a hour, however, under the same experimental conditions, MIP is difficult to form.
2、When I raised the temperature，I can get molecular imprinted polymer after about 1 hour，but the adsorption capacity of MIP and NIP were too small or none.
3、The polymerization reaction is in two states, either not occurred or too acutely.
Unfortunately, i cannot see what problems you face after polymerization. However, if you prefer , you can choose a you functional monomer that is structurally different from the template molecule thereby facilitating facile removal (since methacrylate has low polarity just like your template). Alternatively, you can perform something like dummy imprinting . However, since i do not have an idea regarding your monomer or our template, i cannot promise whether this strategy will be helpful for you or not.
Dear all, please check the following documents. My Regards
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111630/
With an unpolar template perhaps other, less polar monomers are advantageously for the MIP, e.g. vinylpyridine as recognizing monomer and butylmethacrylate or styrene as main monomer. Divinylbenzene can be used as crosslinker. Also the porogen should be unpolar, e.g. toluene.
Thank you for your patience and help, I plan to synthesize MIP according to your suggestions @ Burkhard Koehler
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