The dissolution test in a particular USP monograph uses pooled sampling. We would like to do a dissolution profile comparison using f2 for this product. Can we use the pooled sample results for the calculation of f2?
Hi Vipul,
I don't have any specific experience on pooled sampling and f2, so I will refer you to the FDA guidance and Health Canada's expert on dissolution.
1. https://www.fda.gov/downloads/drugs/guidances/ucm070237.pdf
2. https://www.linkedin.com/in/saeed-qureshi-3664a18/
Usually, we do it by taking n=12 means by taking specific numbers of runs.
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