I want to optimize a process. The process has 12 important process parameters ( 12 factors and each has three levels). I want to use RSM tool. The RSM is best approach with respect to optimization as compared to other techniques. But it is not capable to manage data with 12 factors. it is possible that some one split or divide the whole process into small sections (3 factors and three levels) and then optimize the process. Is it possible that someone divide the large process into small portions/sctions and then do optmization. If yes, have you any research paper for a reference. Can you share with me.

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