MRS can evaluate the rate of GABA or Glutamate or other metabolites in the brain.
The short answer to that would be "no". MRS can evaluate changes in molecules that are detectable by NMR and that are present at concentrations > 0.1 mM however to look at the activity of this transporter you'd need to study either Ca or K which is in itself very problematic and hasn't really been done in vivo. Further, these molecules are involved in many other processes, so isolating the effects of KCC2 would be next to impossible.
Some researchers have studied transporter activity in, for example, red blood cells using NMR spectroscopy but not any potassium channels that I am aware of.
Dear professor
Thank you. I would like to work on the subject related with MRS. I want to know how GABA concentration alters in such disorders. I want to know whether GABA concentration differs or it has an excitatory role in initial stages of disorders?
KCC2 is the second member (2) of the potassium (K) chloride (C) cotransporter (C) subfamily. It does not transport Ca ions.
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