Can someone suggest how to link thioglycolic acid to the N-terminal of peptides that already cleaved from the resin?

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

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Afang Zhang

You could use active ester methodology, but need to protect the thio-group first.

Enrico Perspicace

Dear Sahar Ahmed,

Buy methyl (or ethyl) thioglycolate (it's not expensive) and use standard conditions EDCI/DMAP. It should work. Then, perform the cleavage of the ester with LiOH in a mixture of THF/H2O.

Good luck!

Regards