I have a Waters Xevo TQ MS and the Instrument passes the calibration and resolution only in positive mode. Negative mode keeps failing. Did anyone else notice this issue? What could be a possible solution?
I am using the NaICs calibrations solution. It is in 50/50 IPA/Water. Resolution/calibration passes in positive mode. However, it doesn't see the negative ions. I do see them at an e^6 level when I infuse the calibration solution.