01 January 2017 4 4K Report

What I wonder is that assuming I have two proteins namely protein-A, protein-B and protein A is somehow modified by protein B (simply an enzyme catalyzing the addition of -OH group to certain Proline residues in protein-A), is it feasible to acquire profound insight as to how the protein-B comes closer to the certain sites in the protein-A and initiate the interaction?. More broadly can one be able to investigate how the structure of an enzyme affect what it does in a dynamic way (conformational changes along the catalysis, how the rest of the enzyme rather than the active sites contributes to its function or any important water enzyme interaction etc.). And besides that how one should think of the catalysis process in an intuitive way. What I mean by that is in biochemistry books it is just said that "This enzyme adds Oxygen from the dioxygen in the environment....." I mean how should one imagine this process in a more physical and theoretical way ?. It really bothers me the fact that I just cannot imagine the cascade of events in a more scientific and theoretical manner. Also if these questions are so trivial forgive my ignorance on the matter. Any suggestion would be much appreciated, thanks in advance. 

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