Is it possible to remove N-Boc protection group simply by heating? The t-butyl protecting group of –COOH can be removed by heating at a high temperature (160 °C for 15 h) without acid/ water. But is it possible to achieve this in an amine system (preferably at temperatures < 120 °C )?

Please share your valuable opinions about this.

Thank you

More Anjali Preman's questions See All
Similar questions and discussions