Can I use triethylamine instead of N,N-Diisopropylethylamine for acylation of a secondary amine?

What is the right way to conjugate two acids?

How to conjugate two acids with amine linker?

18 February 2021 4,083 2 View

Mixture neutralization after Boc deprotection ?

I am performing a Boc-deprotection with HCl in organic solvent (dioxane or Ethylacetate) but would like to isolate the free amine. Several problems: - Neutralizing with inorganic base as NEt3...

18 February 2021 3,366 3 View

What is the role of ether solvent (such as THF) in Sonogashira coupling?

Can Amine (such as Et3N) be used as solvent as well as base for the Sonogashira Coupling? How to decide the amount of solvent to be used in any reaction? Does the amount of solvent affect the...

14 February 2021 4,018 3 View

Which solvent is suitable for product precipitation if reaction has been performed in toluene?

If condensation reaction happened between carboxylic acid and amine and amide is formed. The solvent for this reaction is toluene. After completion of reaction, how to collect product? It should...

03 February 2021 9,796 3 View

Is there a way to get rid of TEA in a TLC plate in order to do proper staining?

Dear colleagues: I have been trying to establish a few HP-TLC methods in the lab. In general, for quantification purposes, I prefer CuSO4+acid charring, to primuline staining. Lately I have been...

20 January 2021 9,019 1 View

How to recrystallization amine compound and it is not soluble in common organic solvents ?

19 January 2021 671 3 View

Interpreting and troubleshooting anomalous HPLC results?

I am running a simple isocratic Shimadzu HPLC system coupled to a fluorescence detector to detect and quantify biogenic amines from in vivo samples. But my results are not as expected and I'm...

10 November 2020 7,027 5 View

Can TBDMS protecting group be cleaved under 25% TFA/DCM?

I performed a boc deprotection via 25% TFA/DCM (1 hr) without any workup, which should yield TFA salt as a product. My compound also had a TBDMS group on it. But when I took an NMR, the amine peak...

21 October 2020 4,470 3 View

ELISA against plant viruses?

We are doing DAC ELISA against plant viruses. I have following queries. Controls that we are using are as follows. Buffer control, Healthy leaf samples, disease infected sample (+ve sample), and...

14 October 2020 1,627 2 View

How can i analysis result of gas absorption in gromacs?

Hi every body I want to simulate gas absorption with gromacs. I have a box with three part , amine and water in the middle of box and gas is around of it(gas+amine solution+gas). Firstly I...

02 October 2020 300 2 View

Kachapur Arunkumar

1) ARKIVOC 2005 (vi) 287-292

Abstract

A general method for the direct formation of tertiry amines via direct N-alkylation of secondary amines by alkyl halides in acetonitrile in the pres

ence of Hunig’s base is reported.

2) Synthetic Communications

Mild and Useful Method for N-Acylation of Amines

Pages 2694-2701 | Received 10 Oct 2008, Published online: 26 Jun 2009

https://doi.org/10.1080/00397910802663428

Limitation of acyl chloride if ur using for peptide reaction.

1)Generally Ketenes are formed by reacting an acyl chloride containing an a proton with NEt3.Else TEA can be used for acylation.