Can I use triethylamine instead of N,N-Diisopropylethylamine for acylation of a secondary amine?

More Kastus Shlyk's questions See All

Can anyone suggest a good method to separate Aniline sulfate back to its original form?

26 July 2018 4,825 1 View

Can I use triethylamine instead of N,N-Diisopropylethylamine for acylation of a secondary amine?

29 June 2018 9,200 2 View

Conjugation of PEG-Amine to an Amino Acid Using EDC?

I am attempting to conjugate PEG to an amino acid at the C-terminus, for the purposes of producing nanoparticles. I have been told that PEG modified with amine groups can be used for this purpose,...

31 July 2024 2,033 1 View

When I am trying to distill triethyl amine while drying it over calcium hydride. How do I design the setup to let hydrogen escape without losing NEt3?

I am new to research. The boiling point of triethyl amine (NEt3) is 89 degrees centigrade. I am skeptical that when I will let the hydrogen escape which is getting generated in situ, I will also...

21 July 2024 7,284 4 View

Methods of O-methylation of amino acids without interfering the amine groups?

Hello guys. I have faced the problem of being in need of carboxyl-methylated amino acids. Amino acids I need are not available in the market so I need to synthesize them by myself. So thus I'm...

16 June 2024 9,920 3 View

How to purify Schiff base product?

How to stabilise the Schiff base product and avoid it from reverse back to the aldehyde and primary amine.

09 June 2024 9,264 5 View

How to select aminolysis reaction over transamidation reaction bw an amine and an amide ester?

Hi. i have a molecule it has both amide and ester bond. When i want to get second amide bond with ester part of the molecule by an amine, but it attacks to the amide bond also. In which conditions...

01 June 2024 9,863 2 View

Does anyone know how to Coat polystyrene particles with APTES ?

I want to have amine group attached on the polystyrene particle surface. APTES can be used to do that.

21 May 2024 8,092 0 View

Please suggest procedure for deprotection by HCL in dioxane to make amine ?

Free amine

26 April 2024 4,950 0 View

How can you avoid triethylamine salt precipitation while protecting Secondary amine with acid halide in presence of NEt3 especially in Flow sytem?

protecting Secondary amine with acid halide in presence of NEt3 especially in Flow sytem?

23 April 2024 5,746 1 View

Which solvents and what ratio should I use for TLC to seperate my azo schiff base and azo aldehyde?

I have synthesized an azo Schiff base using an azo aldehyde and an amine. Now I can not separate my compound in TLC plate. I have used n-hexane and ethyl acetate mixture, acetone, and n-hexane...

24 March 2024 1,099 3 View

What are the current concerns about the quality of orthodox black tea and green tea?

I want to know the current concerns about the quality of the final product of Ceylon black tea or green tea. I want to contribute to upgrading the quality of the Ceylon tea, which will lead to...

23 March 2024 6,417 0 View

Kachapur Arunkumar

1) ARKIVOC 2005 (vi) 287-292

Abstract

A general method for the direct formation of tertiry amines via direct N-alkylation of secondary amines by alkyl halides in acetonitrile in the pres

ence of Hunig’s base is reported.

2) Synthetic Communications

Mild and Useful Method for N-Acylation of Amines

Pages 2694-2701 | Received 10 Oct 2008, Published online: 26 Jun 2009

https://doi.org/10.1080/00397910802663428

Limitation of acyl chloride if ur using for peptide reaction.

1)Generally Ketenes are formed by reacting an acyl chloride containing an a proton with NEt3.Else TEA can be used for acylation.