No, I don't think it is necessary to use CCD for detection. But you need to make sure that your filter setting matches the wavelength of Luciferase chemiluminescence, i.e. if it has a peak at 562 nm, you shall use a bandpass filter centered around that.

It should be no problem to use confocal microscope to measure luciferase either with a CCD camera in one of the bright field imaging ports or the PMT in the confocal port. You won't need any excitation to measure the luminescence of the luciferase and you don't necessarily need an emission filter since there is no external excitation. All of the light from the sample is your signal and you want to gather as much of it as possible. The fewer elements in the optical path, the better.

Here are a few papers on chemiluminescence microscopy.

Article Unlocking the Potential of Chemiluminescence Imaging

https://pubs.acs.org/doi/full/10.1021/acscentsci.7b00058

Article Chemiluminescence Microscopy as a Tool in Biomedical Research

Thanks so much for the help!! Really appreciate it :)

Yes ,I mean one trick for that is set it at bright field, make intensity of lesar 0, adjust gain of pmt to give you luceferin signal in confocal, just make sure you adjust 1 airy unit for luceferin spectral maxima,so according to diffraction pattern you will get good image