please am aware of the synergistic relationship that exist between AFB1 and HBV but am trying to follow the cause of high incidence of Hepatitis b infection for a population exposed to AFB1 in food so thinking those afb lead to the development of Hbv and can it be simulated in the lab
Dear Dr. Amadu,
Hepatitis B is a viral infection, which is transmitted through infected body fluids, transfusion, intra-familial contacts etc. While exposure to AFB 1 is through fungus contaminated foods. Although it is epidemiological proven that HBV infection along with AFB 1 exposure results to a high chance of liver diseases, leading to HCC. However, your perception that AFB 1 exposure leads to HBV is not right. A population might have high HBV due to several epidemiological risk factors which are responsible for its transmission, and in parallel the same population may also be exposed to high AFB 1 due to dietary factors. there are a number of studies in sub-Saharan Africa, which attest to this synergism. To the best of my knowledge, there is no data to show that AFB 1 leads to HBV infection, as you have mentioned, or the vice-versa. Hence, with due regards, I think that you might have to modify your hypothesis and study design.
regards,
SD
Thanks Dr S.D for that insightful contribution,your suggestion are fully noted .
Dr S.D. is possible to point me to how i could source for duck hepatitis B positive serum?
- Badges
- Science topic
- Similar topics
- Geoscience
- Asia
- India