I study the effects of protein haptenation in the mechanism of contact allergy and drug allergy, but am curious about whether lipids are also able to be haptenated by chemical sensitisers in tissues. I've tried several literature searches but am not finding anything related to lipid haptenation. This suggests to me either that there isn't much research or that lipids aren't susceptible to haptenation in the same way as proteins.
Dear Pete
Please see Biophys J. Aug 1987; 52(2): 187–197.
doi: 10.1016/S0006-3495(87)83206-X
PMCID: PMC1330070
Dynamic properties of the haptenic site of lipid haptens in phosphatidylcholine membranes. Their relation to the phase transition of the host lattice.
K. Takeshita, H. Utsumi, and A. Hamada
Balakrishnan K, Mehdi SQ, McConnell HM. Availability of dinitrophenylated lipid haptens for specific antibody binding depends on the physical properties of host bilayer membranes. J Biol Chem. 1982 Jun 10;257(11):6434–6439.
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