Most of the studies are on drug resistance (macrolide), typing methods in streptococci. Penicillin resistance is not been reported till now, but we can't completely rely on this antibiotic? Is any kind of animal studies possible?
Streptococcal pyogenes is one of zooanthroponoses. Originally human disease spread by animal or animal product to infect other man and cause suppurative and non-suppurative manifestation. I suugest to study the m.o. in human and animal and detect the genetic relationship between them.