Hi, I am using 3-mercapto propionic acid for an organic reaction as co-catalyst (linker molecule). But it imparting some color impurities to my product and I want to omit it from my reaction. But if I am not using this the time cycle is more and yield is less. So I want to use some other linker molecule for the same reaction instead of 3-mpa. Any one can suggest any other possible molecule. (The reaction is between 4-hydroxy acetophenon and phenol in presence of dry HCl to get 1,1,1 (tris hydroxy phenyl)methane
Dear all;
I join Dr. Xiaobo Gu in that the question is really unclear.Would you please rewrite it and give more details. Regards
@Abdelkader BOUAZIZ and Xiaobo Gu: Yes, I can explain. The reaction is between 4-hydroxy acetophenone and phenol in presence of dry HCl. Dry HCl is first protonating 4-hydroxy acetophenon. Then 3-mercaptopropionic acid linking with its one end to protonated 4-hydroxy acetophenone and with other end to phenol. Because of this mechanism, the two reacting species are coming closer and reaction is speeding up. (Mercaptopriopinic acid has one end thiol group and other end is carboxylic acid group). So this is speeding up the reaction as well as yield also increasing. But the main problem, after the reaction, the product has little brownish colour because of the oxidation of sulfer from 3-mpa (most probably) and it is creating big issue. So I have decided to remove 3-mpa with any other linker molecules. That is why I am now in search of good linker molecule to substitute 3-mpa. I hope the question is clear now and expecting your kind help.
IF I understand right, it looks like the 3-mpa is kind of catalyst for Friedel-crafts acylation. In that case, the sulfur is not necessary,you can replace it with COOH, then use AlCl3 as Lewis acid. Does the sulfur do link the phenol?I think the acid anhydride is the one accelerating the reaction.
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