Can anyone please tell me if the sodium metaperiodate will degrade mRNA?

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Madhukar Baburao Deshmukh

Sodium metaperiodate will degrade mRNA as this reagent has tendency to cleave 1,2-diols. Sugar part present in mRNA will be cleaved by it.

Binbin Cui

Dear Madhukar Baburao Deshmukh,

Can we treat the cells with metaperiodate such that the 1,2-diols of mRNA is cleaved?

Does the cleaving reach requires other conditions like certain PH?

Thank you for your previous answer +-^