I would imagine the protocols would vary depending on the interaction.

I'd start by asking if the interaction involves phase 1 or phase 2 pathways in the liver.

Thank you for your response Jacob. Both please. Thanks.

Dear Ogochukwu,

First, you should design an experimental set based on the distinction of pharmacodynamic and pharmacokinetic interaction. A possible pharmacokinetic herb-drug interaction may be only understood by the determination of drug levels in physiological fluids (biophase). For understanding of a possible pharmacodinamic herb-drug interaction, you should choose a "specific activity experiment for drug"

Regards

Yusuf

Dear Ogochukwu please have a look of  attached paper, it might be helpful.

Regards

Thank you Hajra for your response; it is very helpful.