So my partner is struggling with getting the MORGAN v3.4 (PANGAEA program) parametric linkage to generate appropriate results, there are absurd LOD scores even for the "dummy" data (where they input data that both was and wasn't supposed to give them a suggestive or significant LOD score so they could test that the script was structured correctly and going to give appropriate results). They're trying to optimize both dominant and recessive linkage models, and based on the allele frequencies and penetrances they're inputting they should be getting significant LOD scores but they haven't gotten anything higher than a LOD of 1.2.
Here's the specifics, if anyone would be willing to shed some light on what may or may not be going wrong, we'd be super appreciative. Nobody in their lab or department has used MORGAN before so this is all very trial by error with no supervision.
- Badges
- Science topic
- Similar topics
- Instrumentation Engineering
- Instruments