my work is based on enantioseparation by liquid chromatography. i want some literature about open column chromatography. could anyone help me for this?
I doubt column chromatography will work since it does not have the 'resolving power' to separate chiral centers. Therefore, there are no research papers. This is usually performed by HPLC, UPLC, and GC. In any case you will have to use a 'chiral' column packing like a carbohydrate. For information on column chromatography see this slideshare.
https://www.slideshare.net/shaisejacob/column-chromato?qid=d46efa57-05a4-42fd-92ee-681ad7483e6b&v=&b=&from_search=6
Look at these chiral packings. They will give you an idea.
https://www.phenomenex.com/Products/HPLCDetail/Lux/Cellulose-3?returnURL=/Search&phaseTab=True
http://chiraltech.com/chiral-columns/?utm_source=google%20&utm_medium=cpc&utm_campaign=uschiraltech.com/chiral-columns/?utm_source=google%20&utm_medium=cpc&utm_campaign=us&gclid=CjwKCAjwrO_MBRBxEiwAYJnDLBjjqm4h3FOllqYGXrlBi3P_v5tYL2jRl75vdSTK94z-_46orhC00RoCb5AQAvD_BwE
Look up www.chromacademy.com for the 'resolution equation between peaks' and influences on the separation factor (alpha).
Do you have access to SciFinder or Web of Science? Google Scholar is pretty good as well. Search your topics there. Open tubular LC is currently of academic interest only. Although there is an interest in open tubular for sending chromatographs in space without a pump. Nobody uses open tubular chiral columns for industrial work. All columns are packed columns. If you cannot access a particular article, share the link here.
Flash chromatography has the ability to resolve chiral compounds; I've done it and it can work, especially for well resolved compounds.
However, for chiral resolution, the largest cost is in the chiral media and not the column or packing the column. The media that works is 20 micron particles, smaller particles cause back pressure so high that pumps are needed Even at 20 micron, some solvents (such as 2-propanol) make high back pressure such that pumps are required. The column does need to be very well packed as well. Given these constraints, open column enantiomeric separation isn't generally useful.
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