M in due need of propargylated toluene by using 3-bromopropyline as the starting material. Please help me
REAXYS gives the following detail:
With potassium carbonate in N,N-dimethyl-formamide at T=20°C;
The corresponding literature hit is this:
Mo, Juntae; Choi, Wonseok; Min, Jiae; Kim, Cheol-Eui; Eom, Dahan; Kim, Sung Hong; Lee, Phil Ho
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11382 - 11388
Link: http://pubs.acs.org/doi/abs/10.1021/jo401922b
Is something like this what you are looking for:
Li, Q; Gau, H "Synthesis of allenes via nickel-catalyzed cross-coupling reaction of propargylic bromides with Grignard reagents" Synlett 2012, 23(5), 747–750x.x.2012
Both the allene and propargyl compounds are formed in this reaction.
Is it substituted toluene or the unsubstituted one? Where exactly in the molecule do u want to propargylate?
Dear Vijay V., I want to propargylate the CH3 group of toluene.
Sudarsan VenkatRamani ji, Will you please elaborate the process?
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