M in due need of propargylated toluene by using 3-bromopropyline as the starting material. Please help me
REAXYS gives the following detail:
With potassium carbonate in N,N-dimethyl-formamide at T=20°C;
The corresponding literature hit is this:
Mo, Juntae; Choi, Wonseok; Min, Jiae; Kim, Cheol-Eui; Eom, Dahan; Kim, Sung Hong; Lee, Phil Ho
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11382 - 11388
Link: http://pubs.acs.org/doi/abs/10.1021/jo401922b
Is something like this what you are looking for:
Li, Q; Gau, H "Synthesis of allenes via nickel-catalyzed cross-coupling reaction of propargylic bromides with Grignard reagents" Synlett 2012, 23(5), 747–750x.x.2012
Both the allene and propargyl compounds are formed in this reaction.
Is it substituted toluene or the unsubstituted one? Where exactly in the molecule do u want to propargylate?
Dear Vijay V., I want to propargylate the CH3 group of toluene.
Sudarsan VenkatRamani ji, Will you please elaborate the process?
The reaction is being proceeded in Ethanol and DMF as and when required. Sometimes in the mixture of both. 'M getting the good IR and TLC confirmation for the completion of reaction. But the...
08 September 2014 3,274 4 View
How to calculate the RMSD values for a MD simulation using MOE?
07 August 2021 0 0 View
When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.
16 June 2021 0 0 View
effect of double bond on the flexibility of polymers
07 April 2021 0 0 View
I am writing to request some information for making polymer color flakes. I would appreciate the help.
17 March 2021 0 0 View
I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...
03 March 2021 3,661 2 View
I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...
02 March 2021 8,437 2 View