During embryonic condition of twins, some genes are switched off and some are switched on. Here in this process cytosine get attaches to the CH3 then 5- methyl cytosine will be formed.
Why only cytosine is attached to methyl group and forms switched off gene. Why not other nitrogen bases attaches to methyl?
Thank you. GD
to understand that epiphenomena it good to have a look on the enzymes encompassing these reaction in the nucleus. Dig in epigenetic literature
these paper could help you as well
http://www.nature.com/cr/journal/v21/n3/full/cr201115a.html
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040924
Epigenomics
publié par Anne C. Ferguson-Smith,John M. Greally, Ph.D.,Rob A. Martienssen
Literature on switching genes on and off is easily available. For introductory text and references the following that is available on research gate can be referred to:
Sharma K. Lamarckism Revisited: Epigenetic Interface with Environment Challenges ‘Gene as Fate Theory’ and Rewrites the Rules of Disease, Heredity, and Identity: A Case Study of Discordant Monozygotic Adult Twin Pair for a Psychiatric Disorder. Indian J. Phys. Anthrop. Hum. Genet. 30:167-181.
I think Michele Kere has it right. The answer lies in the substrate specificity of the methylating enzyme as determined by its conformation.
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