Article How to Recognize, Respond to, and Prevent Anaphylaxis: A Com...

Yes, anaphylaxis can occur without a known trigger, a condition referred to as idiopathic anaphylaxis. In these cases, the cause of the allergic reaction remains unknown despite thorough investigation and testing. Idiopathic anaphylaxis is relatively rare, but it can still pose significant challenges in diagnosis and management.

While the trigger may not be identified, individuals with idiopathic anaphylaxis still experience the typical symptoms of anaphylaxis, including skin reactions, difficulty breathing, gastrointestinal symptoms, and cardiovascular effects. Prompt recognition and treatment, including the use of epinephrine if necessary, are crucial in managing idiopathic anaphylaxis.

Despite the lack of a known trigger, individuals with idiopathic anaphylaxis should work closely with healthcare professionals to develop an appropriate management plan, which may include measures to avoid potential triggers, carry emergency medications, and respond effectively to allergic reactions as they occur.