Caffeine has been recently established as potential memory enhancer and neuro-protective. It has also been shown to enhance the long term potentiation (LTP), one of the major memory forming processes in brain.
What do u think "whether this could be employed against Alzheimer disease and what should be the approach to establish this therapy".
...in the past years coffee has a real bad image (blood pressure et al.), but I think coffee can contribute to fight against oxidative stress (cell protection) like tea (the green one ;) ) or red wine...=>polyphenole.
you can find a lot of (serious) studies about that topic.
cheers (with coffee?!)
martin
Hi Andi,
yes, I´m only know that coffeine has protective effects (A2a- and A2b-adenosine receptor antagonists) against AD and Parkinsonism.
There is a good review article (J.W.Daly,"Caffeine analogs: biomedical impact", Celll.Mol.LifeSci. Vol.64,2007), but I guess that you already know this paper. But it isn`t so specific (dose-ranges and binding affinity are mainly not discussed).
Anyway, I think the main ponit is the prevention effect of coffeine and other heterocycles against diseases triggered by oxidative stress.
In which way do you think the sympathomimetic effects would decrease the positive effect of caffeine?
best regards,
Martin
"Coffeine as a protective factor in dementia and alzheimer`s disease", Eskelinen et al., J. of AD 2010
in this "review" they sum up 9 studies...3-5 cups of coffee per day (approx. 350mg coffeine) was associated with a decreased risk of dementia/AD about 65%....
what do you think about this dose-range and the genetic background (ApoE)?
In the Journal of Alzheimer Disease volume 20 supp 1 are a huge amount of reviews about caffeine and dementia
hi all,
we do find out that caffeine may help reduce a risk factor of AD, chronic neuroinflammation (brothers and al., 2010). Will it treat AD? after all these years, i end up believing that only a multi approach will help out at least modify disease progression. start with coffee, wine and tea, that can't hurt (at least low doses..)
Problem of caffeine is the aspecificity consequence of the degradation products. And I do not think that caffeine can cure AD, just decrease risk.
Despite that mechanisms involved in the protection are really interesting to understand better the disease, starting treating cells or animals with caffeine to stop disease seem really unrealistic.
By the way, in PD field, many people use high dose of caffeine to stress cells (http://www.ncbi.nlm.nih.gov/pubmed/22988096).
Cheers!
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