Deficiency of vitamin B12 increases the risk of cognitive impairment. Please take a look at the following RG links.

Article B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

Article Cognitive impairment and vitamin B12: A review

Scientists understand that the hope for the miraculous effect of a group of vitamins, one of the receptor ligands, a popular instant messenger is always an echo of advertising. In a living organism, a balance of many regulatory substances, signal molecules, trophic factors that function harmoniously with different functional states of the body has been formed. With the development of the pathological process, this balance is violated, and to hope for a "saving" effect after correction of one of the regulatory factors is groundless. In the last resort, you can achieve a temporary positive effect. Please see the article in the attachment.

Hi Dr Dennis,, Vit B1,B6 and B12 have important role in regulation of CNS function. Difficiency of all these vitamins can cause neurological symptoms. Among all these Vit B12 has important role in cognition.. Thanks

Deficiency of vitamin B12 increases the risk of cognitive impairment. Please take a look at the following RG links.

Article B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review

Article Cognitive impairment and vitamin B12: A review

The B-vitamins are an essential group of vitamins to help the body function. In total, there are eight B-vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). These are water-soluble vitamins which means they are not readily stored in the human body and are easily excreted by the kidneys. B vitamins function as either cofactors for enzymes for optimal performance, or as precursors to other important molecules.

Recent cross-sectional and longitudinal studies have provided evidence for an association between these B vitamins and many aspects of cognitive performance and have raised the possibility that even subclinical differences in nutritional status may have a subtle influence on aspects of cognitive performance, especially in older adults and in clinical populations.

You can see the following links:

https://academic.oup.com/psychsocgerontology/article/56/6/P327/610645

https://thesunlightexperiment.com/blog/2018/1/26/b-vitamins-and-cognitive-function-should-i-be-interested

There are three B vitamins that play specific roles in the brain and nervous system. Vitamins B6, B9, and B12 are considered the major players when it comes to brain health. The brain loves B vitamins and they are an important consideration for improving memory and cognition as well as lowering your risk of mild cognitive impairment (or “pre-dementia”) and Alzheimer’s.

Please return to the links below:

https://universityhealthnews.com/daily/memory/b-vitamins-for-memory-and-mild-cognitive-impairment-science-proves-they-are-essential/

https://www.health24.com/Lifestyle/Healthy-Nerves/how-b-vitamins-could-boost-your-memory-20160216

With regards