Considering that schizophrenia is a brain disease that can be found using fMRI and looking for enlarged ventricles I think it is important to do a brain scan before considering such an illness. Many people are skeptical, we need to define excessive skepticism of reality and how the person is functioning in a daily life setting? Skepticism of reality does not always equal schizophrenia, perhaps there are manipulative people in their lives who change the stories they are told? This can cause serious doubt about reality. External factors such as this need to be considered first, followed by brain abnormalities.
Not sure why you equate excessive scepticism and schizophrenia. Although the comment above is fine, recording some of the assumptions about schizophrenia, many people without these abnormalities have been diagnosed as suffering from the illness. Others have attempted to learn from it.
Why enlarged ventricles nevertheless should cause schizophrenia remains uncertain. Scepticism is necessary here. I remember a lab scientist from my old university, Kings College, who found psychopathy in black gangland members using brain scans. We see what we want to see!
Fabrizio, yes. A valid point. Also although I originally said nothing I did work on the matter of brain abnormality producing Schizophrenia and, although indeed this might be true, my doubts were immediately raised.
Recently I read a book by an established neurologist (name forgotten) who speculated that the brain was a gland. If that is the case rather than an overgrown nerve end then it would function like other glands and such abnormalities would as likely be extensive not localised. I was then reminded of the neurologist who checked street gang members for psychopathology, finding it in their white matter. All were black! Or the professor who decided every one in prison was psychopathic. No one of course could have been wrongly convicted or driven by circumstance!