Some of my colleagues contend that for oral administration a larger number of vegetative CFU are better than spore CFU from efficacy point of view. However, from my microbiology lessons I remember that spores are better equipped to survive through gastric acid and bile.
All comments, views, advice and suggestions are welcome.
Thanks
-Parimal
Hi,
Well, if your spores vegetate in the environment that you want to inoculate them in, so technically using spores is more reliable than vegetative form. However, you may be able to introduce them as vegetative form and bypass gastric environment by using capsules. If you have the ability, go ahead and do a comparative study to better understand which one is the best!
Best
Hi, as stated by Ali Hassan, of course for a consumers' product, spores are better to withstand stomach acid and bile acid challenges and the product's stability over longer shelf-life. The real problem is that the 'gold-standard' probiotic strains of the genus Lactobacillus or Bifidobacterium are not spore formers. So, we have to find a strain that survibes acid challenges, techniques for better viability over prolonged shelf-life and delivery vehicle . But there are other probiotic spore formers as in the genus, Bacillus (aerobic) and Butyribacterium, Clostridium (anaerobic), etc. Good luck.
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