This a question that I posed and I think I have an answer, in the article Houck, PD. Why is there a young woman advantage? Why is it lost? Applying the laws of biology to men and women. JCvD 2014. In press.

The underlying importance of this article is it addresses the immune system as a modifiable risk factor to detect and prevent cardiovascular disease. How we modify this system to prevent heart attacks and strokes still needs to be identified. The answer for women is to maintain a shifting Th1/ Th2 immunity with variable doses of estrogen. How to shift men from Th1 predominance will require more imagination.