Are cyclin D and cyclin E both needed for a cell to have the G1/S transition, or only one of them is enough?

Dan Cacsire Castillo-Tong @Dan-Cacsire-Castillo-Tong

16 May 2018 1 8K Report

Cyclin D/CDK4/CDK enables G1/S transition, cyclin E/CDK2 does the same. Can someone tell me, if both are needed or one of them will be enough to get cells to S? Thank you. Dan

Eugen Werwein

This is a quite complicated topic with hundreds of research reports analyzing cyclin requirements in various cell systems. Assuming an unperturbed cell cycle, Cyclin D acts upstream of the Cyclin E enabling the initiation of the cell cycle (G0/G1 transition), Cyclin E then stimulates entry into the S-phase (G1/S transition). However, there are compensatory mechanisms so that cells with Cyclin D or Cyclin E knockout might still be able to proliferate.

Here are some nice reviews as a starting point:

Article Living with or without cyclins and cyclin-dependent kinases

Article Mammalian cell-cycle regulation: several Cdks, numerous cycl...

Good luck!

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