Aspergillus flavus and Aspergillus oryzae are very closely related species (just as A. parasiticus is with respect to A. sojae). However, A. flavus is pathogenic and A. oryzae is GRAS. It has been widely accepted that, through domestication, A. oryzae lost the ability to produce alfatoxins (though biosynthetic clusters are present in its genome), nevertheless little has been signaled about the genomic gains compared to A. flavus, specially regarding its exohydrolytic apparatus. My question, for you mycologists and -hopefully- Japanese food biotechnologists, is whether A. flavus has the same hydrolytic potential to turn gelatinized cereal grains into koji. Some authors (Shurtleff & Aoyagi) claim that one would be able to make koji by spontaneous fermentation, and I am thus wondering if the substrate poses a sort of axenic pressure. Also, if A. oryzae is a millenary domesticated ecotype of A. flavus, is it plausible for it to become of cosmopolitan distribution? I am going bananas suspecting there are aflatoxins in my koji.