Hello,
I am working on a project measuring a number of oxidative stress biomarkers in the urine of clinical samples. We are particularly interested in 8-OH-dG and f2isoprostanes, but we are having problems with the sensitivity of our method. We cannot get anywhere near reported literature measurements for these markers using a Thermo TSQ Vantage. Has anyone used the Vantage for these markers in urine successfully? I am a clinical researcher, but can easily get details on the LC-MS method from our collaborator if there are suspicions of something being up with the actual method (although we suspect it is machine related).
Thanks,
Daniel
Hey Harald,
We are trying to both. 8-OH-G appears to be fine, but we really wanted to get the 8OHdG and F2ISO in the same run. May have to do a couple runs in the end. Thanks for the suggestion.
CHeers,
Daniel
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