Transcription factors are known to carry out activation and repression of downstream genes simultaneously. But does the change in functionality correlate with discrete changes in binding motif signatures?
In this case i am looking for evidence that RREB binding motifs might be connected to repressive elements
Hello Aritra.
Motif association is not quite elucidated. That is a good news to you. Thus, you could start from the following papers.
- p16INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB (2003)
- Finb, a multiple zinc finger protein (aka RREB1), represses transcription of the human angiotensinogen gene (2004)
- The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer (2007)
- The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease (2014)
Regards.
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