Any online method to determine the percentage of random or helical structure in short peptides and to determine the three-dimensional structure.
Dear Hussein Algboory ,
Depending on how short your short peptides are there are various options. For the first part of your question on how to get an idea about the secondary structure you can choose between numerous secondary structure predication programs, see for an overview of a small collections (and comparison between the results obtained, Table 2): Article The role and significance of potential lipid-binding regions...
For the second part of your question, the 3-D models/predictions can be obtained by for example:
-PEP-FOLD server ( https://bioserv.rpbs.univ-paris-diderot.fr/services/PEP-FOLD/ and/or https://bioserv.rpbs.univ-paris-diderot.fr/services/PEP-FOLD3/ )
-Or I-TASSER (https://zhanggroup.org/I-TASSER/ ) minimum peptide length should be 10, depending on the extent of detail and accuracy the way how to deal with the results obtained by I-TASSER can be found for example here: https://www.frontiersin.org/articles/10.3389/fphar.2021.731828/full or Article Prediction of Lipid-Binding Regions in Cytoplasmic and Extra...
and https://www.researchgate.net/publication/328368498_keller3biotech2015suppldocxBest regards.
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